All posts by Kenneth Dantzler-Corbin

I am a writer, editor, adjunct professor of Religion and Philosophy, English as a Second Language, Genealogy, Educator in Ambulatory Care, and Spiritual Support Specialist, Singer, Musician, and Social Justice Advocate for Human Rights.
Ancestry, genealogy, History

President Ulysses S. Grant the 18th president of the United States, 23rd cousin 2x removed.

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President Ulysses S. Grant is my 23rd cousin 2x removed. The ancestor who connects us as relatives is, Maud DE SAINT LIZ (-1140), my 21st great grandmother.

Historical narrative. Ulysses S. Grant (born Hiram Ulysses Grant; April 27, 1822 – July 23, 1885) had been an American soldier, politician, and international statesman who served once in the 18th president of the United States from 1869 to 1877. During the American Civil War, General Grant, with President Abraham Lincoln, led the Union Army to success throughout the Confederacy. During the Reconstruction Era, President Grant led the Republicans inside their efforts to remove the vestiges of Confederate nationalism, racism, and slavery.

From very early childhood in Ohio, Grant had been a skilled equestrian that has a talent for taming horses. He graduated from western Point in 1843 and served with distinction into the Mexican–American War. Upon his return, Grant married Julia Dent, and together they had four children. In 1854, Grant suddenly resigned through the army. He along with his family members struggled financially in civilian life for seven years. If the Civil War broke call at 1861, Grant joined the Union Army and rapidly rose in rank to general. Grant was persistent in the pursuit of the Confederate enemy, winning major battles and gaining Union control of the Mississippi River. In March 1864, President Lincoln promoted Grant to Lieutenant General, a rank previously reserved for George Washington. For more than a 12 months Grant’s Army of the Potomac fought the Army of Northern Virginia led by Robert E. Lee into the Overland Campaign and also at Petersburg. On April 9, 1865, Lee surrendered to Grant at Appomattox, therefore the war ended.

On April 14, 1865, Lincoln ended up being assassinated. Grant continued his service under Lincoln’s successor President Andrew Johnson and had been promoted General of the Army in 1866. Disillusioned by Johnson’s conservative way of Reconstruction, Grant drifted toward the “Radical” Republicans. Elected the youngest 19th Century president in 1868, Grant stabilized the post-war nationwide economy, developed the Department of Justice, and prosecuted the Ku Klux Klan. He appointed African-Americans and Jewish-Americans to prominent federal offices. In 1871, Grant developed the very first Civil Service Commission. The Democrats and Liberal Republicans united behind Grant’s opponent when you look at the presidential election of 1872, but Grant had been handily re-elected. Grant’s new Peace Policy for Native Americans had both successes and problems. Grant’s management successfully resolved the Alabama claims in addition to Virginius Affair, but Congress rejected their Dominican annexation initiative. Grant’s presidency was affected by many public scandals, while the Panic of 1873 plunged the country as a serious economic downturn.

After Grant left office in March 1877, he embarked for a two-and-a-half-year globe tour that captured favorable global attention for him plus the United States. In 1880, Grant had been unsuccessful in getting the Republican presidential nomination for a 3rd term. When you look at the last 12 months of his life, dealing with severe investment reversals and dying of neck cancer tumors, he wrote his memoirs, which turned out to be a significant critical and financial success. At the time of their death, he was memorialized being a sign of national unity.

Historic assessments of Grant’s legacy have diverse quite a bit through the years. Historians have hailed Grant’s military genius, along with his methods are featured in armed forces history textbooks. Stigmatized by numerous scandals, Grant’s presidency has traditionally been rated among the worst. Contemporary scholars have shown greater appreciation for their achievements that included civil rights enforcement and also have raised their historic reputation. Grant happens to be seen as an embattled president who performed an arduous work during Reconstruction.

The genealogical chart with the ancestor who connects us as relatives:

President Ulysses S. Grant (1822 – 1885)
23rd cousin 2x removed

Jesse Root Grant (1793 – 1874)
Father of President Ulysses S. Grant

Noah Grant (1772 – )
Father of Jesse Root Grant

Noah Grant
Father of Noah Grant

Martha Huntington
Mother of Noah Grant

Abigail Lathrop (1665 – 1745)
Mother of Martha Huntington

Elizabeth Scudder (1622 – 1700)
Mother of Abigail Lathrop

Elizabeth Stoughton ( – 1647)
Mother of Elizabeth Scudder

Rev. Thomas Stoughton (1557 – 1622)
Father of Elizabeth Stoughton

Francis Stoughton
Father of Rev. Thomas Stoughton

Mary Exhurst
Mother of Francis Stoughton

Joan Roberts
Mother of Mary Exhurst

Isabel Colepepper
Mother of Joan Roberts

John Colepepper (1424 – 1480)
Father of Isabel Colepepper

Agnes Roper (1390 – 1457)
Mother of John Colepepper

Edmund Roper
Father of Agnes Roper

Beatrix Lewknor
Mother of Edmund Roper

Roger Lewknor ,Sir
Father of Beatrix Lewknor

Thomas Lewknor , Sir
Father of Roger Lewknor ,Sir

Joan de Keynes
Mother of Thomas Lewknor , Sir

Richard de Keynes
Father of Joan de Keynes

Sarah de Huntingfield
Mother of Richard de Keynes

Sir William de Huntingfield
Father of Sarah de Huntingfield

Alice de St. Liz
Mother of Sir William de Huntingfield

Saher I de Quincy
Father of Alice de St. Liz

Maud de St. Liz
Mother of Saher I de Quincy

Maud of Northumberland
Mother of Maud de St. Liz

Maud DE SAINT LIZ ( – 1140)
Daughter of Maud of Northumberland

disease, Health

Would you like to know about the drug delays type 1 diabetes in people at high risk?

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Remedy affecting the disease fighting capability effectively slowed down the progression to medical type 1 diabetes in high-risk individuals, relating to findings from National Institutes of Health-funded research. The research is the first to exhibit that medical type 1 diabetes could be delayed by several years among those who are at high risk. These results were published on-line in The brand New England Journal of Medicine and delivered during the United States Diabetes Association Scientific Sessions in San Francisco bay area. The research, involving treatment with an anti-CD3 monoclonal antibody (teplizumab), ended up being conducted by Type 1 Diabetes TrialNet(link is outside), an international collaboration geared towards discovering approaches to postpone or avoid kind one diabetes. Scientists enrolled 76 participants ages 8-49 have been family members of individuals with type 1 diabetes, had at the very least two types of diabetes-related autoantibodies (proteins produced by the immune protection system), and unusual sugar (sugar) tolerance.

Participants were randomly assigned to either the therapy team, which received 14 days of teplizumab or even the control group, which received a placebo. All participants received glucose tolerance tests regularly until the analysis was completed, or until they developed medical kind one diabetes – whichever came first.

Throughout the test, 72% of individuals within the control group developed clinical diabetes, in comparison to only 43% for the teplizumab team. The median time for individuals into the control team to build up medical diabetes was just over two years, while those that developed clinical diabetes into the therapy group possessed a median time of 48 months before progressing to diagnosis.

“The difference between results ended up being striking. This finding could be the first evidence we have seen that medical type 1 diabetes could be delayed with very early preventive therapy,” said Lisa Spain, Ph.D., Project Scientist through the NIH’s nationwide Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), sponsor of TrialNet. “The outcomes have crucial implications for individuals, especially youth, that have family relations because of the infection, as individuals can be at high-risk and reap the benefits of early assessment and therapy.”

Type 1 diabetes develops if the immune system’s T cells mistakenly destroy the body’s very own insulin-producing beta cells. Insulin is needed to transform glucose into energy. Teplizumab targets T cells to minimize the destruction of beta cells.

“Previous medical research funded because of the NIH discovered that teplizumab effectively slows the increasing loss of beta cells in individuals with current onset clinical kind 1 diabetes, nevertheless the drug had never been tested in those who didn’t have medical condition,” said Kevan C. Herold, M.D., of Yale University, the study’s lead author. “We wished to see whether the early intervention could have good results for those who are in risky but do not yet have the signs of type 1 diabetes.”

The results for the medication were best in the 1st 12 months after it was given, when 41% of participants developed clinical diabetic issues, mainly into the placebo team. Many facets, including age, may have contributed to your capability of teplizumab to delay medical infection since at-risk children and adolescents are known to advance to kind one diabetes faster than adults. Faster progression of type 1 diabetes is connected with a compelling disease fighting capability, which could explain the impact of immune system-modulating medications like teplizumab.

Other data collected from the trial can help researchers to comprehend why specific individuals took care of immediate therapy. Participants who reacted to teplizumab tended to have particular autoantibodies as well as other immune protection system faculties. The research team additionally cautioned that the research had limits, like the small wide range of participants, their absence of ethnic diversity, and therefore all individuals were family relations of men and women with kind one diabetes, possibly restricting the capability to convert the research broadly. “While the results are motivating, more research needs to be done to handle the trial’s restrictions, as well as to comprehend the mechanisms of action, long-term efficacy and security for the treatment,” said Dr. Spain.

“This trial illustrates how decades of research from the biology of type 1 diabetes can result in promising treatments which have a substantial effect on people’s lives. We are very excited to begin to see the next steps in this research,” said Dr. Griffin P. Rodgers, NIDDK Director. “The dedicated researchers, volunteers, and families taking part in this program make discoveries such as this possible.”

TrialNet provides initial screening(link is external) for relatives of individuals with type 1 diabetes while offering follow-up screening and participation in clinical trials to those people who are discovered to have increased risk for developing a medical condition, all free.

Reference
NIH study finds heavily processed foods cause overeating …. http://homelesslivesmatterberkeley.org/2019/05/16/nih-study-finds-heavily-processed-foods-cause-overeating-and-weight-gain-national-institutes-of-health/

Fitness

In fitness: Did you know that CrossFit enthusiasts more prone to injury?

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Current research compared the favorite regime’s high-intensity workouts to the traditional weight training exercise.

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CrossFit workouts are notable for their strength, combining rate with regular weight training and calisthenic exercises. Exercises regarding the day (WODs) usually involve doing as many reps as possible (AMRAP) in a limited period. However, while there is no doubting its appeal — you can find 13,000 CrossFit gyms much more than 120 countries — CrossFit has usually run afoul of workout traditionalists who believe speed, and weight lifting does not mix.

Given CrossFit’s reputation, it is no surprise that the very last decade has produced several studies checking out damage rates among individuals. Despite a deep dive to the realm of CrossFit, results have already been equivocal: some studies suggest the rate of damage is not any more than in other leisure sports, as well as others suggest that CrossFit enthusiasts are undoubtedly prone to damage.

An element of the reason there is such a selection of outcomes is the fact that there is no one standard concept of injury. Depending on the study, damage can vary anywhere from the stoppage in training or a trip up to a healthcare professional to allowing research topics to self-determine if they are hurt. The wider this is, the higher the sheer number of injuries recorded. However, the most recent study, published in the might problem of the Orthopaedic Journal of Sports Medicine, took a somewhat various approach, comparing damage rates of CrossFit and traditional weight training exercise enthusiasts inside the same geographic location and the same period.

The investigation team distributed a questionnaire asking about damage history to seven gyms in Pennsylvania, three of which defined as CrossFit gyms. They additionally distributed the questionnaire to individuals on several e-mail lists linked to the Hershey infirmary and Pennsylvania State University College of Medicine. They received 411 reactions — 122 from CrossFit participants and 289 from those that advertised to follow along with a far more traditional weight training exercise routine.

The CrossFit group had more females and had been over the age of the old-fashioned weightlifting group, but both sets of exercisers resolved about four times per week so that you can take two hours per session. About half the respondents from both groups reported being injured within the last few couples of years, because of the CrossFit participants 1.3 times more prone to be injured and 1.86 times prone to get medical assistance.

The shoulder ended up being the most frequent web site of injury among all participants, followed closely by the lower as well as sides. Neat and jerk lifts, dead-lifts and snatch motions had been the workouts probably to cause injury among the list of CrossFit participants. Within the traditional weightlifting group, barbell and dumbbell bench press exercises, dead-lifts and straight back squats had been often related to damage. Men were much more likely than ladies to obtain hurt both in CrossFit and traditional weight training exercise routines.

Despite the high rate of problems for CrossFit individuals, the investigation team, recommended it had been the strength of this exercise, perhaps not the workouts themselves, that resulted in more injuries. They stated that  “many of the same workouts and the body regions are taken into account the same percentage of injury in both CrossFit and conventional weightlifting groups.”

CrossFit boasts of a culture that pushes individuals to their real restrictions — which will be when type and method may start to have sloppy. While the intensity, competitive atmosphere and fast speed of this work out are really what more and more people find compelling, workout specialists have long preached that after the technique is sacrificed in preference of more reps, damage risk escalates.

For the record, CrossFit has asked that the Orthopaedic Journal of Sports Medicine withdraw the paper, saying it “is beset with medical error, cites retracted studies that contained fabricated data and inaccurately cites other studies concerning our CrossFit® brand.” CrossFit has aggressively pursued a few medical journals that published studies suggesting that injury rates among CrossFit participants are more than in other kinds of workouts.

Nevertheless, the outcomes of the most recent study do not suggest the injury prices can be worth abandoning all of that makes CrossFit so accessible. The camaraderie, competition, and work out variety are positives. Problems occur whenever a method is compromised as a result of tiredness. Therefore the more physically demanding and much more technical lifts or exercises must be done early in work out, before exhaustion sets in. Alternatively, the tradition should switch to put more value on technique, in the place of on notching another rep or completing a set in record time.

CrossFit has had people and kept individuals during the fitness center. It has also fundamentally changed the way we exercise when you are an extremely early adapter of high-intensity interval training. That said, not absolutely all CrossFit gyms are manufactured equal; some staff tends to be more knowledgeable and respectful of exercise technique than the others. Then when it comes to CrossFit or another workout, never sacrifice strategy in preference of one last rep.

Reference
5 Great Uses of the Internet | Easy Work Great Pay. https://www.easywork-greatpay.com/blog/5-great-uses-of-the-internet/

Diet, disease, Health

Excellent 5 things you need to cut out of your diet in order to reduce high blood pressure and lower the risk of heart failure

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You may be everything you do not consume.

A diet that can help people reduce high blood pressure or hypertension might also lessen the chance of heart failure in people underneath the chronological age of 75, based on research published into the latest version of the United States Journal of Preventive Medicine, and led by doctors at Wake Forest School of Medicine, which will be section of Wake Forest Baptist Health in Winston-Salem, N.C.

Photo by Valeria Boltneva on Pexels.com

‘Only a couple of previous research reports have examined the consequences for the Dash diet in the incidence of heart failure, and they have got yielded conflicting results.’— Claudia Campos, Wake Forest Class of Medicine

An observational study greater than 4,500 people over 13 years revealed that those people under 75 whom most closely adhered towards the Dash diet had a considerably lower danger of developing heart failure compared to those who were least likely to stick to the tenets associated with the diet. (Dash means for Dietary ways to Stop Hypertension.)

“Only a couple of previous research reports have examined the results regarding the Dash diet in the incidence of heart failure, and they have got yielded conflicting outcomes,” said Claudia Campos, associate teacher of essential interior medicine at Wake Forest School of Medicine. “Following the Dash diet can lessen the possibility of developing heart failure by almost half.”

The study recommends cutting five things from the diet: This Dash diet recommends fruits, veggies, nuts, whole grain products, poultry, fish and low-fat dairy food while reducing the use of three main components: salt, red meat, sweets, and sugar-sweetened beverages. It is very just like the Mediterranean diet. Nevertheless, the Dash diet recommends reducing two more things: full cream (and only low-fat milk products) and alcohol consumption.

There are various other approaches to eat healthiest too. Those who eat gradually are less inclined to become overweight or develop a metabolic problem, a group of cardiovascular illnesses, diabetic issues and stroke danger factors, following research presented during the American Heart Association’s Scientific Sessions 2017. They might be more aware of what they are eating and drinking and tend to be less prone to overeating.

The Dash diet is quite like the Mediterranean diet, but, unlike that diet, it advises low-fat milk products and excluding alcohol consumption.

Dietitians also advise against snacking and takeouts. Men and women have less control over what gets into their dishes when they order in. Americans get a majority of their daily sodium — more than 75% — from processed food and restaurant food, in line with the Centers for Infection Control and Prevention. Individuals eat, on average, 200 calories more per meal if they eat food from restaurants.

“Excess salt can boost your blood pressure levels as well as your risk for cardiovascular disease and stroke,” the Centers for Infection Control and Prevention states. “Together, cardiovascular illnesses and stroke kill more Americans each year than just about any other cause.” Americans get 71% of the day-to-day sodium from processed and restaurant meals. Cooking on your own could be the best and healthiest option.

Artificially sweetened beverages could be associated with a heightened risk of stroke and dementia, following the American Heart Association’s peer-reviewed journal Stroke. Another 2015 study unearthed that older ladies who consume several diet carbonated drinks per day are 30% prone to suffer a cardiovascular occasion. Include that to more research suggesting regular soft drink is related to obesity.

Reference
5 things to cut out of your diet right now to reduce high …. https://www.marketwatch.com/story/these-simple-but-critical-changes-to-your-diet-can-help-reduce-high-blood-pressure-and-lower-risk-of-heart-failure-2019-05-14

Diet, disease, Health, Healthy eating

Why don’t fats make a person fat? A Dietitian explains how it might be the opposite

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Professionals have some excellent news to fairly share: no, eating fats does not automatically make you fat. Overeating, macronutrient (fat, protein, or carbs) boosts the threat of weight gain, said registered dietitian Kristin Kirkpatrick at Cleveland Clinic Wellness, but “fat in and of itself just is not a thing that is likely to make you fat,” despite the somewhat misleadingly identical terminology.

You can understand where in actuality the misconception arises from, however. “Fat can be a fairly scary nutrient” for individuals who count calories, Kristin said, since it is more calorie-dense: one gram of fat contains nine calories, in comparison to four calories per gram of protein and four calories per gram of carbohydrate. “People also may associate fat with more ‘indulgent’ foods, such as butter and steak,” Kristin told POPSUGAR, adding to the misconception that every fat are unhealthy. Then there is the simple association that eating fats might create fat within the body, which is not just the situation; you are likely to gain weight if you eat processed or processed foods or overeat consistently, including fats, but fats do not inherently lead to weight gain.

Kristin said, nearly all her clients have now been able to lose weight on high-fat diets, often since they replace refined carbs and sugars with healthy fats (snacking on nuts as opposed to pretzels, for example). The popular ketogenic diet, which can be high-fat and low-carb, is the one which has helped many people drop some weight, even though it is still controversial among dietitians.

According to Kristin, fats will also be harder to digest than other nutrients, such as carbs. This means they take longer to move throughout your digestive system, that will help you stay full for longer and have fewer snacking cravings. Fats improve your metabolism for the same reason; the body needs more energy (aka burns more calories) to digest them.

Exactly how much fat should you eat, then? On average, seek to keep fats as 30 percent of one’s healthy daily diet, though Kristin noted that this would probably vary based on the body, activity level, and general health; consult a health care provider or dietitian for guidelines specific to the body. You ought to also adhere to healthy fats as much as possible, including avocados, nuts, whole soy, olive oil, and fatty fish like tuna and salmon.

So no, you most likely do not need to go nonfat to get rid of weight or remain healthy. Keeping those healthy fat sources as part of your regular diet, balanced with carbs and much protein, is the better way to go.

Reference
Does Eating Fat Make You Fat? | POPSUGAR Fitness. https://www.popsugar.com/fitness/Does-Eating-Fat-Make-You-Fat-46237336

Diet, disease, Health, Healthy eating

New study links people who don’t get enough sleep to poor nutrition

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Study links people who don’t get enough sleep to poor nutrition

Poor sleep has been connected to poor nutrition. However, it is unclear why the two may appear together. The association between the issues was revealed in a study that looked at National Health and Nutrition Examination Survey data, based on the American Society for Nutrition, which unearthed that individuals who sleep lower than seven hours per night might also lack adequate levels of vital nutrients.

Following the CDC, adults should get more than seven hours of sleep per night to maintain their health. The brand new study unearthed that US adults who got not as much as that number also, an average of, consumed fewer nutrients like vitamins D and A, zinc, niacin, and more.

Some vitamins and minerals are vital for health but are not created by the body. Someone with a poor diet could be with a lack of at least one of these micronutrients, eventually leading to disruption in normal bodily functions, or perhaps the introduction of diseases or any other problems.

As well as a connection between poor sleep and poor nutrition, the study found that more nutrients were connected to poor sleep in females; taking vitamin supplements reduced the amount, based on the study, hinting at a potential benefit from supplementing to fill the nutritional gaps in one’s diet.

The findings may be revealed because of the study’s lead author Chioma Ikonte in the annual American Society for Nutrition meeting. The type for the study means the researchers were not able to find out whether someone suffers poor sleep quality because of poor nutrition, or if perhaps poor sleep quality eventually results in nutritional deficits.

Reference

Study links people who don’t get enough sleep to poor …. https://www.slashgear.com/study-links-people-who-dont-get-enough-sleep-to-poor-nutrition-09579778/

disease, Health

It is interesting that body fat distribution linked to higher risk of aggressive prostate cancer

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Micrograph showing prostatic acinar adenocarcinoma (the most common form of prostate cancer) Credit: Wikipedia

In the first prospective study of directly measured body fat distribution and prostate cancer risk, investigators unearthed that higher levels of abdominal and thigh fat are associated with an increased danger of aggressive prostate cancer. Published early online in a peer-reviewed journal associated with the American Cancer Society, the findings can result in a significantly better knowledge of the partnership between obesity and prostate cancer and supply new insights for treatment.

Previous research reports have shown that obesity is related to a heightened chance of advanced prostate cancer and a poorer prognosis after diagnosis. Also, emerging evidence shows that the precise distribution of fat in the torso may be an essential factor.

To offer high-quality evidence, Barbra Dickerman, Ph.D., associated with the Harvard T.H. Chan School of Public Health, along with her colleagues analyzed body fat distribution using the gold-standard way of measuring computed tomography imaging and assessed the possibility of being identified as having, and dying from, prostate cancer among 1,832 Icelandic men who were followed for up to 13 years.

Throughout the study, 172 men developed prostate cancer, and 31 died from the disease. The accumulation of fat in specific areas—such as visceral fat (deep in the abdomen, surrounding the organs) and thigh subcutaneous fat (just under the skin)—was associated aided by the threat of advanced and fatal prostate cancer. High body mass index (BMI) and high waist circumference were also connected with higher risks of advanced and fatal prostate cancer.

Interestingly, when looking separately at men with a high BMI versus low BMI, we discovered that the association between visceral fat and advanced and fatal prostate cancer was stronger among men with a lower BMI. The precision of these estimates was limited in this subgroup analysis, but this might be an intriguing signal for future research.

Additional studies are needed to investigate the role of fat distribution when looking at the development and progression of prostate cancer and exactly how alterations in fat stores as time passes may affect patients’ health. Ultimately, identifying the patterns of fat distribution, which are from the highest risk of clinically significant prostate cancer might help to elucidate the mechanisms linking obesity with aggressive disease and target men for intervention strategies.

An accompanying editorial notes that lifestyle interventions—such as diet and exercise—that target fat loss may also reduce the risk of prostate cancer.

Reference
Body fat distribution linked to higher risk of aggressive …. https://medicalxpress.com/news/2019-06-body-fat-linked-higher-aggressive.html

Can Fat Thighs Give You Cancer? Study Finds Link Certain …. https://uevf.org/cancer/fat-thighs-give-cancer-study-finds-link-kinds-obesity-aggressive-prostate-cancer-68666028

Diet, disease, Health

It is interesting that Vitamin D supplement does not prevent type 2 diabetes in adults at high risk, study finds

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Taking a daily vitamin D supplement will not prevent type 2 diabetes in adults at high risk, according to results from research funded by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), an element of the National Institutes of Health. The Vitamin D and Type 2 Diabetes (D2d) study enrolled 2,423 adults and was conducted at 22 sites throughout the united states of America. These findings were published June 7 into the New England Journal of Medicine and presented during the 79th Scientific Sessions regarding the American Diabetes Association in San Francisco bay area.

2d may be the most extensive study to directly examine if daily vitamin D supplementation assists in maintaining people at high risk for type 2 diabetes from developing the illness. The analysis included adults aged 30 or older and assigned participants randomly to either take 4,000 International Units (IU) for the D3 (cholecalciferol) kind of vitamin D or a placebo pill daily. All study participants had their vitamin D levels measured at the beginning of the study. During those times, about 80% of participants had vitamin D levels considered sufficient by U.S. nutritional standards.

“Observational studies have reported an association between lower levels of vitamin D and increased risk for type 2 diabetes,” said Myrlene Staten, M.D., D2d project scientist at NIDDK. “Additionally, smaller studies discovered that vitamin D could improve the function of beta cells, which produce insulin. However, whether vitamin D supplementation might help prevent or delay type 2, diabetes had not been known.”

The analysis screened participants every three to half a year for an average of 2.5 years to ascertain if diabetes had developed. Researchers then compared how many people in all the two study groups which had progressed to type 2 diabetes. At the end of the analysis, 293 away from 1211 participants (24.2%) in the vitamin D group developed diabetes in comparison to 323 out of 1212 (26.7%) into the placebo group – a difference that failed to reach statistical significance. The study was made to detect a risk decrease by 25% or even more.

D2d enrolled a different number of participants with a variety of physical characteristics, including sex, age, and body mass index, as well as racial and ethnic diversity. This representation helps ensure that the analysis findings could be widely applicable to people at high risk for developing type 2 diabetes.

As well as the study’s size, certainly one of its major strengths could be the diversity of their participants, which enabled us to examine the effect of vitamin D across a sizable number of people. When the study ended, we found no meaningful difference between the two groups, no matter age, sex, race, or ethnicity.

Reference
NIH-funded trial finds vitamin D does not prevent type 2 …. https://www.nih.gov/news-events/news-releases/nih-funded-trial-finds-vitamin-d-does-not-prevent-type-2-diabetes-people-high-risk

disease, Health

Do you know in milestone trial, experimental drug delays type 1 diabetes?

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Marking the culmination of a 33-year odyssey, scientists today report a milestone in type 1 diabetes: the first occasion the illness happens to be markedly delayed in young adults at high risk. Presenting in the American Diabetes Association meeting in San Francisco and publishing simultaneously when looking at the New England Journal of Medicine, researchers found that two weeks of an experimental intravenous drug held off disease by on average about e of years.

The mainstay of type 1 diabetes treatment is insulin, discovered 97 years ago. These results open an innovative new chapter, says Jeffrey Bluestone, an immunologist at the University of California, San Francisco bay area, and the first research team. “On the only hand,” the outcome is “pretty exciting,” Bluestone says. “On one other hand, now the actual time and effort begin.” Which will mean considering just how to move this treatment forward and probing whom it is most very likely to help?

The clinical trial began eight years back and included 76 people, the youngest of whom were 8 yrs. old plus the oldest within their 40s. Nearly three-quarters were 18 and under. Each had an incredibly high danger of type 1 diabetes. In this autoimmune disease, the body attacks cells within the pancreas, which make insulin, which helps keep blood glucose levels under control. Because of the time diabetes is diagnosed, a lot of these insulin-producing cells, called beta cells, have left.

Reference
In milestone trial, experimental drug delays type 1 …. https://ehealthynews.com/2019/06/10/in-milestone-trial-experimental-drug-delays-type-1-diabetes-science-magazine/

Diet, disease, Health, Healthy eating

It is amazing that scientists dream of a personalized diet based on Genetics

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No single food regimen works well with everyone. New research is one of comprehensive effort yet to understand why.

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Photo by Pixabay on Pexels.com

A decade ago, spurred by the success of the Human Genome Project and the affordability of genetic sequencing, scientists started to explore the promise of “nutrigenomics.” Could personalized nutrition, informed by understanding of an individual’s DNA, assist in preventing and even
treat diet-related diseases?

The outcome of early studies from Harvard, Stanford and elsewhere were compelling: Genetic differences did actually predispose individuals to lose different levels of weight on different sorts of diets. A multimillion-dollar industry soon sprang up, premised on marketing DNA-based diets. But subsequent studies have failed to demonstrate any statistically significant difference between fat reduction between overweight individuals who “eat suitable for their genotype” and the ones that do not.

In fact, the result of genes on obesity has been hard to tease out; various studies put the figure at anywhere from 35 to 85 percent. Nutritionists have traditionally observed that no body weight-loss strategy works well with everyone, and that individuals show striking differences in their responses to different diets.

Reference
Diet for One? Scientists Stalk the Dream of Personalized …. https://monohealthy.com/diet-for-one-scientists-stalk-the-dream-of-personalized-nutrition-the-new-york-times/