The biggest Alzheimer’s study ever finds new genes and pathways involved in disease progression.
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The groundbreaking study’s findings imply physicians can better anticipate whether a patient is genetically prone to Alzheimer’s. Alzheimer’s disease affects over 5.8 million Americans. Researchers from France’s Université de Lille performed the study. A genetic risk score may help determine who is most likely to develop Alzheimer’s.
To better understand Alzheimer’s and create medicines that delay or prevent the disease start, the research represents a huge step forward. The next stage is for researchers to concentrate on the study’s risk genes and their influence in brain cell malfunction and death.
The genome of a single sperm contains the genetic material of one pair of paternal chromosomes.
Researchers are re-analyzing 92 percent of the genome to look for genetic variants that may be causing illnesses. “We identified many more, tens of thousands, if not hundreds of thousands” of new variants, says David Dennis. In addition, researchers can better investigate how centromere proteins assemble and what happens when they alter or lose function using the new genome. As part of his research, Evan Eichler aims to decode the genetic code on paternal and maternal chromosomes. By systematically sequencing a large number of individuals from diverse origins, he claims that it would be possible to better understand the genetic variation of the globe and identify relevant genetic variants.