Novel antiviral medication for Covid-19

Merck and Ridgeback Biotherapeutics’ Molnupiravir is a novel antiviral medication. If approved by the FDA, it will be the first oral home therapy for COVID-19.

Molnupiravir, an antiviral drug to treat mild to moderate COVID-19, is under consideration by the FDA for possible authorization.

Molnupiravir, a five-day tablet regimen, looks less effective than monoclonal antibodies. The Pfizer medicine Paxlovid may be more effective. Both tablets inhibit viral replication by targeting certain steps. Concerns about molnupiravir do not immediately relate to Paxlovid, as Pfizer has not yet made its safety data public. Exist any hazards or adverse effects?
Waiting a few days for a test and a few days for findings means the most effective time for these tablets has past.

Will they work against omicron and its variants?
Particular tests pitting the tablets against specific versions are required, say Dieffenbach and Gandhi.

The antiviral medicines target a distinct stage of the virus’ life cycle.

If approved by the FDA, these antiviral tablets might be effective, but stronger antivirals are needed, adds Dieffenbach. “These variations will continue till COVID rates fall,” Gandhi said. Treatments: “They are a back-up.


New antiviral drugs are coming for COVID. Here’s what you need to know.

Individuals tested positive for Covid-19

According to Dutch authorities, 61 individuals who landed in Amsterdam on two planes from South Africa tested positive for Covid-19. Individuals being tested on different flights from South Africa.

The Dutch authorities are doing more testing to see if there are any instances of Omicron, which was declared a variety of concern by the WHO on Friday.

On 24 November, the variation was initially reported to the World Health Organization in South Africa.

By that time, the Dutch authorities had already imposed travel restrictions from the area due to the new variety and arranged for travellers to be tested and quarantined.

The Dutch health authorities said on Saturday that 61 passengers on the planes had tested positive.

The positive test findings will be analyzed immediately to ascertain if they pertain to the new concerning variety, which has been dubbed the Omicron variant, the company stated in a statement.

Anyone who tested positive would be required to stay at a hotel for seven days if they exhibited symptoms and five days if they did not, the statement continued.

According to reports, some passengers have not received formal confirmation of a negative test and hence are unable to board subsequent flights.


Covid: Dozens test positive on SA-Netherlands flights.

What is Your Opinion on the Benefits of Coffee for Alzheimer’s Disease? Here’s What the Latest Research Says About the Link.

In a study evaluating the relationship between coffee and tea consumption and the risk of dementia and stroke, the researchers revealed that a certain number of cups consumed per day had the highest association with a decreased risk.

That is the message from recent research that is generating much attention. The research, published in the journal PLOS Medicine on November 16, assessed data from 365,682 adults aged 50 to 74 who took part in the UK Biobank. (If you are not acquainted with the UK Biobank, it is a large-scale biomedical database and research resource.) The health of the individuals and their coffee and tea consumption habits were monitored for 10 to 14 years.

During the research, 5,079 people got dementia, and 10,053 people had at least one stroke. The researchers examined persons who did not drink coffee or tea to those who did and discovered that those who enjoyed their brewed beverages had a reduced risk of stroke and dementia than abstainers. Those who drank two to three cups of coffee or three to five cups of tea per day had a decreased risk of dementia and stroke. Those who drank two to three cups of coffee and two to three cups of tea per day—so four to six cups of coffee and tea per day—had the most outstanding outcomes, with a 32% reduced risk of stroke and a 28% lower risk of dementia.

“We discovered that consuming coffee and tea individually or together was connected with a decreased risk of stroke and dementia,” the researchers concluded. “Consumption of coffee alone or in conjunction with tea was linked to a decreased incidence of poststroke dementia.”

It is worth noting that the research discovered merely a relationship, not causality. That is, the researchers did not discover that drinking coffee or tea reduces a person’s chance of dementia or stroke; instead, they discovered that persons who consume coffee and tea had a decreased risk of these primary health conditions. Scott Kaiser, MD, a geriatrician and the director of Geriatric Cognitive Health at Providence Saint John’s Health Center in Santa Monica, California, tells health that the correlation vs. causation component is critical. He emphasizes that the research “does not establish that consuming coffee or tea caused this decrease in risk.”

Doctors are still interested. “He is delighted that coffee drinking may reduce my own risk of dementia,” Amit Sachdev, MD, medical director in the Department of Neurology at Michigan State University, tells health.

This is not the first research to discover a correlation between coffee, in particular, and good health. For example, one research of over 468,000 adults, presented in August at the European Society of Cardiology, showed that drinking up to three cups of coffee per day is associated with a decreased risk of stroke and heart disease. In addition, a meta-analysis of 34,282 people’s data published in the journal Clinical Nutrition in 2016 discovered that drinking one or two cups of coffee per day is associated with a decreased risk of dementia.

Of course, there is such a thing as too much of a good thing. For example, research published earlier this year in the journal Nutritional Neuroscience discovered that consuming more than six cups of coffee each day increases your chance of developing dementia.

The “considerable disagreement” around the link between coffee and tea intake and stroke and dementia is one of the reasons the researchers claim they undertook this most recent study.

It is unclear why there could be a relationship between coffee and tea use and dementia and stroke risk—and the new research did not look into this. “While caffeine is undoubtedly a crucial shared denominator,” Dr. Kaiser explains, “coffee and tea are both derived from plants with many, many potentially beneficial chemical components, including strong antioxidants.” Any of these phytonutrients—chemicals produced by plants to maintain their health—”can really lower inflammation in our brains, protect brain cells from damage, improve learning and memory, and give other obvious advantages for brain health,” he continues.

All of this begs the question: Should the individual start drinking coffee or tea if the individuals are not already? Dr. Sachdev does not recommend it. “He is a little doubtful that this research will affect behavior,” he adds. “He would be more interested if a specific chemical in coffee or tea could be discovered.”

However, if one is already a coffee or tea user, individuals will be relieved to discover that the daily habit may be linked to a decreased risk of dementia and stroke.


Korin Miller, Can Drinking Coffee Lower Your Dementia Risk? Here’s What New Research Says About the Association, November 17,Health. 2021.

Did you know that Germany debates imposing tighter rules as infections surge?

Treating Covid-19 patients at a hospital in Leipzig, Germany, on Monday.
Treating Covid-19 patients at a hospital in Leipzig, Germany, on Monday.Credit…Waltraud Grubitzsch/DPA, via Associated Press

On Tuesday, about 40,000 new cases were recorded in the nation. In the 24-hour period, 236 individuals died from the sickness. “They have a true emergency scenario,” says Dr. Christian Drosten. Since the outbreak, Germany has recorded around 97,000 Covid fatalities. On Wednesday, officials in Bavaria announced a state of emergency, citing a 68 percent increase in cases in the past two weeks. Several additional states, particularly those that have been affected the hardest, have enacted or are about to implement stronger laws this week.

For anyone wishing to access specific services, the guidelines would require vaccines or paperwork demonstrating a previous illness. Approximately 67 percent of the population is completely immunized.


Germany debates imposing tighter rules as infections surge.

Would like to know more on how cause of neurological COVID-19 symptoms are explored?

The Society for Neuroscience is the world’s biggest organization of scientists and doctors working on brain and nervous system health concerns. The virus that causes COVID-19, SARS-CoV-2, obtains entry into the brain and produces neurological symptoms. Fever, cough, fatigue, and loss of taste or smell are the most frequent respiratory symptoms of the virus. Dr. Kumar believes his results will aid in the development of future medications to prevent or cure the disease’s neurological symptoms. “We evaluated the expressions of NRP1 and furin in postmortem human brain tissue out of curiosity, and both of these molecules are abundant in all critical brain areas, including the olfactory and hippocampus,” the researchers said.

“The virus may enter the brain via the nose through the olfactory neurons, and their infection can also explain the loss of smell as a significant symptom in COVID-19.”


Cause of neurological COVID-19 symptoms explored.