Tag Archives: high-risk COVID patients

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The latest Covid-19 vaccines from Pfizer and Moderna

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The latest Covid-19 vaccines from Pfizer and Moderna tend to be exceptionally effective at avoiding severe illness. Scientists are worried that if vaccinated people are silent spreaders of the virus, they could keep it circulating in their populations, putting unvaccinated people in danger. In certain respiratory infections, like the current coronavirus, the nose is the primary access stage. Vaccines are inserted directly into the tissues to activate the immune system to generate antibodies. This seems to be ample security to discourage the individual from being vaccinated from being sick.


Next-generation coronavirus vaccines can trigger immunity in the nose and the rest of the respiratory tract. Mucosal vaccinations are safer than intramuscular procedures to keep respiratory viruses from arising. The lungs are far more open than the nose or mouth to circulating antibodies. Vaccine studies did not produce results about how many patients became afflicted with the infection but showed no effects. The amount of the virus that you replicate in the nose can be decreased if one gets sick, says the immunologist. An informed guide to the global epidemic can be found at com/Heroes.


Coronavirus vaccinations demonstrate robust safety from being ill. Life can return to normal only when civilization as a whole has an inadequate defense against coronavirus. For the time being, even vaccinated citizens would continue to use masks to prevent indoor crowds. The Pfizer and BioNTech vaccines are given as an injection through the arm, as most traditional vaccines. The injection will not be any different from that one had previously, and there are no significant side effects. Moderna and Pfizer vaccines utilize a genetic molecule to activate the immune response. The enzyme, known as mRNA, is ultimately killed by the body. The mRNA is wrapped in an oily bubble that can fuse into a cell, enabling the molecule to slide in. The cell uses mRNA to produce coronavirus proteins that may activate the immune system. The mRNA will only survive for at most a few days until it is lost.

Reference
Here’s Why Vaccinated People Still Need to Wear a Mask. https://www.nytimes.com/2020/12/08/health/covid-vaccine-mask.html

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More than 100,000 Americans are in COVID-19 hospital

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More than 100,000 Americans are in COVID-19 hospital, while the nation has recorded its one-worst daily death toll since the pandemic began.

COVID Tracking Project data show 100,226 people hospitalized on Wednesday with coronavirus disease — a figure that has been steadily rising for weeks. Meanwhile, 3,157 new deaths were recorded on Wednesday, surpassing April 15’s previous peak of 2,607 deaths, according to Johns Hopkins University.

The number of hospital beds in COVID-19 patients far outstrips peaks of around 59,000 in mid-April and July. Early last month, the number of hospitalizations again reached that mark and has been increasing ever since.

About 273,000 people have died from COVID-19 since the first cases were identified in January.

Record-breaking numbers news hits the same day. Announced a major step in the development of coronavirus immunizations, formally approving Pfizer and BioNTech’s emergency vaccine.

Reference

U.S. Hits 100,000 COVID-19 Hospitalizations; More Than 3,100 Deaths. https://www.npr.org/sections/coronavirus-live-updates/2020/12/02/941902471/u-s-hits-100-000-covid-19-hospitalizations

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The CDC has updated its guidelines on the spread of COVID-19

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The CDC has updated its guidelines on the spread of COVID-19. The CDC describes near contact as being within six feet of the person infected for 15 minutes or more during a 24-hour span. It is difficult to identify the current guidelines on which the health departments depend to perform touch tracing. The signs of the infection vary from minor symptoms to extreme illness, according to the CDC. It is not clear if the public has undergone proper instruction on proper selection and use of respiratory PPE, such as N95, for close interaction with an infectious person wearing a respiratory mask. Symptoms of the disease include: fever, chills, shortness of breath, trouble breathing, sore throat, and muscle aches, the CDC says. The disease can last 2-14 days after exposure to the virus and can be serious or moderate in some cases, it says. It is not clear if an affected person has signs for more than two days after being exposed to coronavirus, the Agency states.

Reference

CDC revises “close contact” definition. https://www.emergencyemail.org/newsemergency/anmviewer.asp?a=23565&z=58

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It has been more than 300 days since Chinese authorities first told the World Health Organisation

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It has been more than 300 days since Chinese authorities first told the World Health Organisation that Wuhan residents were sick with a mysterious virus. Scientists discovered soon what the virus was (a coronavirus) and what it did (make people ill with a disease called COVID-19), and it spread across the globe like flames.

More than 1 million people have died worldwide, hundreds of thousands get sick every day, and the United States is the world’s most significant disease.

Researchers were still unsure how the virus spread, why people were infectious, or whether one could get it twice when we released our first guide to the coronavirus. These questions may have some residual confusion, but scientists have made some remarkable strides in responses.

Reference
The global death toll from COVID-19 surpasses 1 million – CNET. https://www.cnet.com/health/global-death-toll-from-covid-19-surpasses-1-million/

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Some Covid-19 patients experience a long-lasting skin issues following the infection

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Some Covid-19 patients experience a long-lasting skin issues following the infection, researchers from Massachusetts General Hospital are finding, including rashes, hives, and “Covid toes,” underpinning previous, limited research about a collection of new symptoms connected with Covid-19 and yet another troubling sign that for a few the herpes virus could have an enduring impact.

The research unearthed that some patients reported skin issues for as much as five months, though an average of patients only experiences observable symptoms for 12 days.

This set of Covid-19 symptoms contributes to mounting evidence that, for a few, the illness may be a long haul — lots of people are now calling this the “long Covid.”

Symptoms varied in severity, though generally mild, researchers said, you need to include rashes, hives, and chilblains, the very last of that your researchers have termed “Covid toes.”

The findings that have been presented in the EADV Virtual congress Thursday and result from studying the info of nearly 1,000 long Covid cases in 39 different countries may help scientists comprehend the body’s inflammatory reaction to Covid-19 infection.
Reference
‘Covid Toes,’ Rashes, And Hives: New Research Underpins …. https://www.forbes.com/sites/roberthart/2020/10/29/covid-toes-rashes-and-hives-new-research-underpins-covid-19s-long-term-skin-impact/

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The spread of the Covid-19 among members in a family group

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The spread of the Covid-19 among members in a family group after one individual is infected is “common” and occurs quickly after illness onset, relating to new research through the US Centers for Disease Control and Prevention.

The person exposed or suspected of experiencing Covid-19 should always be isolated before getting tested, and before test outcomes get back to protect others in the home, said the analysis, published Friday when looking at the CDC’s Morbidity and Mortality Weekly Report.

“Because prompt isolation of persons with #COVID-19 can lessen household transmission, persons who suspect which they could have COVID-19 should isolate, stay in the home, and employ an independent bedroom and bathroom if feasible,” wrote a CDC-led team of researchers.
All people in family members should also wear masks all of the time per space, the group said.

Referencehttps://www.cnn.com/2020/10/30/health/household-spread-covid-19-wellness/index.html
Household spread of Covid-19 is common and quick, a new CDC study finds. https://www.cnn.com/2020/10/30/health/household-spread-covid-19-wellness/index.html.

disease, drugs, Health, medications, Pharmaceuticals

Regeneron Pharmaceuticals has paused critically ill COVID-19 patients’ enrollment

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Regeneron Pharmaceuticals has paused critically ill COVID-19 patients’ enrollment with its trial studying the antibody cocktail treatment, which was fond of President Trump earlier this month. The choice is because of potential safety concerns.
The drugmaker on Friday said it was suspending the enrollment of hospitalized #COVID-19 patients requiring high-flow oxygen or mechanical ventilation after an unbiased monitoring committee observed “a potential safety signal and an unfavorable risk/benefit profile at the moment.”

The enrollment of individuals in this category should be on hold, pending the collection and evaluation of additional data.

Trials continue to test the antibody cocktail in hospitalized patients necessitating little if any extra oxygen. Other trials involving mild or moderately ill patients also can move ahead.

The drug has revealed encouraging outcomes. Regeneron on Wednesday said early data confirmed the therapy lowered COVID-19 related medical visits by 57 percent.

Regeneron earlier this month asked the foodstuff and Drug Administration for emergency approval and said it could make doses accessible to the American people free of charge. The drugmaker said it might have sufficient doses for 300,000 people when looking at the coming months.

Reference

Regeneron stops enrolling critically ill COVID-19 patients …. https://news.immitate.com/2020/10/30/regeneron-stops-enrolling-critically-ill-covid-19-patients-for-antibody-drug-trial-thehill-the-hill/.

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Resistance to Covid-19 infection remains for at least five months

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Resistance to Covid-19 infection remains for at least five months, investigators reported — and probably lengthier than that.

While the study may seem perplexing and contradictory to a comparable report out of Britain this week, it is not. People’s bodies generate an army of immune substances in response to an infection, and many are complicated at first, succumbing off quickly, while others develop more gradually.

The new account out Wednesday reveals 90% of men and women who recover from #Covid-19 infections maintain a stable antibody reaction.

British study demonstrates proof of subsiding immunity to Covid-19.

Although some researchers have suggested antibodies to this virus go away rapidly, experts have found just the reverse — that more than 90% of individuals who were moderately or averagely ill produce an antibody response strong adequate to counteract the virus, and the response is preserved for countless months.
This is important for successful vaccine improvement.

Can one get infected with Covid-19 two times? It is challenging
The team examined the antibody responses of more than 30,000 people who tested positive for Covid-19 at Mount Sinai’s Health System between March and October. They characterized their antibody reactions as minimal, moderate, or high. At least 90% had moderate to high amounts, or titers, of antibodies to the virus’s surge protein — the structure it uses to grip the cells it infects.

They then accurately studied 121 individuals who restored and contributed their plasma — once three months after they first produced signs, and again five months later.
Reference
Immunity to coronavirus lingers for months, study finds. https://www.cnn.com/2020/10/29/health/covid-immunity-lingers-months-wellness/index.html

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A sizable English study showed the sheer number of individuals with Covid-19 antibodies declined significantly

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A sizable English study showed the sheer number of individuals with Covid-19 antibodies declined significantly throughout the summer, suggesting that having the virus may well not confer long-lasting immunity from future infection.

The survey of 365,000 adults in England who tested themselves in the home using a finger-prick test showed the proportion of men and women testing positive for #Covid-19 antibodies declined by 26.5% between June 20—12 weeks following the peak of infections when looking at the country—and Sept. 28.

The outcome also suggested that folks who did not display symptoms were expected to lose detectable antibodies before they showed symptoms. The analysis, conducted by Imperial College London and Ipsos Mori polling organization, was funded because of the British government, which announced the outcome and published the analysis on Monday night. Other experts have not yet reviewed the outcome.

Doctors do not yet know whether antibodies confer any effective immunity against reinfection by Covid-19. However, just because they are doing, and the link between this survey is confirmed, it suggests the outlook of widespread, long-term herd immunity into the virus should be tough to achieve. Herd immunity occurs when enough people in a population develop an immune response, either through previous infection or vaccination, so the virus cannot spread quickly, and those who are not immune have protection.

The findings showed that 18-24-year-olds lost antibodies at a slower rate than those aged 75 and over. The littlest decline of 14.9% was of men and women aged between 18 and 24 years, together with the largest decline of 29% was of men and women aged 75 and over.

The analysis reflects earlier smaller trials and implies that antibodies into the virus decline over 6-12 months after infection, such as other seasonal coronaviruses, for instance, the common cold. The analysis does not indicate whether other kinds of immune responses—such as that contributed by so-called T cells—would help drive back reinfection.

The analysis showed that 6% of England’s population had antibodies on June 20, compared to 4.4% on Sept. 28. After September, 9% of individuals displayed antibodies in London, compared to just 1.6% in all affected regions when looking at England’s southwest.

Among ethnic groups, 13.8% of Black people tested with antibodies at end-September and 9.7% of Asians—mainly South Asians. This is compared to 3.6% of white people. Minority ethnic groups, when looking at the U.K., such as the U.S., have suffered disproportionately through the virus.
Reference
Study Shows Covid-19 Antibodies Waning Over Time, Suggesting Immunity May Wear Off. https://www.msn.com/en-us/health/medical/study-shows-covid-19-antibodies-waning-over-time-suggesting-immunity-may-wear-off/ar-BB1aqa1Z?li=BBnb7Kz

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A brand new study made headlines this week that features people claiming mouthwash could combat COVID-19

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A brand new study made headlines this week that features people claiming mouthwash could comba#t COVID-19.

Mouthwash is a day to day item that’s employed by many people several times just about every day. Also, it could have a large impact if it becomes a possible cure or treatment for the #coronavirus.
The analysis was launched this week by a Penn State College of Medicine research team led by Craig Meyers. They found certain oral antiseptics and mouthwashes could have the capability to inactivate human #coronaviruses.

https://wthr.com/embeds/video/507-6a81e8c9-e83a-4dbe-8d7b-f338b070a1af/iframe?jwsource=cl

Several tables into the study’s text show that one to two minutes of utilizing Johnson & Johnson baby shampoo as a nasal rinse inactives significantly more than 99% for the present virus while at the very least 30 seconds of Crest Pro-Health, Listerine Antiseptic, Listerine Ultra, Equate Antiseptic, CVS Antiseptic Mouthwash, and Betadine 5% bottles of mouthwash inactivate up to or maybe more than 99.99% of virus in your mouth.

As well as the tested mouthwashes that were less efficient still took care of most of the virus. “Most for the common over‐the‐counter mouthwashes/gargles tested demonstrated at the least a 90% decrease in infectious virus at 1 min of contract time using the greater part of products showing increasing virucidal activity with longer contact times,” the research said.

Reference
VERIFY: Study shows mouthwash may inactivate coronavirus, but not a cure.https://www.wthr.com/article/news/verify/verify-study-mouthwash-inactivate-coronavirus/507-98dcc164-17a8-42b3-bc84-5b55dd100f1d