Did you know that genetically engineered immune cells fight off deadly virus in mice?

Researchers may have demonstrated a novel way to safeguard us from some of the world’s deadliest viruses. By genetically engineering immune cells, which will make more effective antibodies, they usually have defended mice from a potentially lethal lung virus. Precisely the same strategy can work in humans against diseases, which are why there are not any vaccines. Though, vaccines typically contain a disabled microbial invader or shards of their molecules. They stimulate immune cells known as B cells to crank out antibodies that target the pathogen. Not every person who receives a vaccine gains protection, however. Some patients’ antibodies are not up to snuff, for example. Moreover, researchers have not been able to develop vaccines against some microbes, such for example HIV additionally the respiratory syncytial virus (RSV), that causes lung infections mainly in children and folks with impaired immune systems.

To find out whether transplanting the modified cells could prevent infections, the scientists injected the genetically engineered B cells or control cells into mice and then exposed the animals to RSV. Five days later, the lungs of this control mice teemed utilizing the virus. However, the lungs of mice that had received the engineered cells contained almost no RSV, the researchers report today in Science Immunology. As soon as the researchers injected the modified B cells into mice with defective immune systems—a common problem in bone marrow recipients, who will be prone to RSV—the rodents could fight off the virus 82 days later.

Did you know that dangerous pathogens use sophisticated machinery to infect hosts?

Gastric cancer, Q fever, Legionnaires’ disease, whooping cough—through the infectious bacteria that can cause these dangerous diseases are each different, each of them utilize the same molecular machinery to infect human cells. Bacteria make use of this machinery, called a Type IV secretion system (T4SS), to inject toxic molecules into cells and also to spread genes for antibiotic resistance to fellow bacteria. Now, researchers at Caltech have revealed the 3-D molecular architecture for the T4SS from the human pathogen Legionella pneumophila with unprecedented details. This might, in the foreseeable future, enable the growth of precisely targeted antibiotics for the diseases above.

There are nine different types of bacterial secretion systems, Type IV being the absolute most elaborate and versatile. A T4SS can ferry a multitude of toxic molecules—up to 300 at once—from a bacterium into its cellular victim, hijacking cellular functionality and overpowering the cell’s defenses.

Current antibiotics act broadly and wipe out bacteria through the body, including the beneficial microorganisms that are now living in our gut. As time goes by, antibiotics might be designed to block just the toxin delivery systems (including the T4SS) of harmful pathogens, rendering the bacteria inert and benign with no perturbing the body’s so-called “good bacteria.”

Watch for Tick, they spread disease

Sometimes, particularly harsh winter will put a dent in Minnesota’s deer tick population. Think about it as nature’s way of rewarding humanity after a long, cold winter. Only deer ticks transmit Lyme disease.

Cold weather only kills ticks if they are confronted with the frigid air.

Ticks were insulated under a thick blanket of snow this winter, and so the bitter cold did not reach them.

The Health Department urges individuals who spend some time in brushy or wooded areas to safeguard themselves from ticks through the use of repellents which contain DEET, the same ingredient that wards off mosquitoes.

Much more useful are products that contain permethrin. However, Regular tick checks will also be recommended. One tip for locating the tiny deer ticks is always to step into the sunlight and look for reflections away from their backs.

Read more at: https://www.mprnews.org/story/2019/05/17/did-the-frigid-winter-take-a-toll-on-ticks

Vice President Joseph Biden, 20th cousin 1x removed

Vice President Joseph Biden is my 20th cousin 1 x removed. The ancestor who connect us together is Maud Marshall (1192 – 1248), my 19th great grandmother.

Joseph Robinette Biden Jr. is an American politician who served as the 47th vice president associated with the United States from 2009 to 2017. Biden also represented Delaware when you look at the U.S. Senate from 1973 to 2009. A member associated with the Democratic Party, Biden is an applicant for President into the 2020 election.

Biden was born in Scranton, Pennsylvania, and lived there for 10 years before moving along with his family to Delaware. He became an attorney in 1969 and was elected into the New Castle County Council in 1970. He had been first elected towards the U.S. Senate in 1972, as he became the sixth-youngest senator in American history. Biden was re-elected into the upper house of Congress six times and was the fourth most senior senator as he resigned to assume the vice presidency in ’09. Biden was a long-time member and former chairman of the Foreign Relations Committee. He opposed the Gulf War in 1991, but advocated U.S. and NATO intervention into the Bosnian War in 1994 and 1995. He voted in favor of the resolution authorizing the Iraq War in 2002 but opposed the surge of U.S. troops in 2007. He has got also served as chairman of the Senate Judiciary Committee, dealing with issues associated with drug policy, crime prevention, and civil liberties. Biden led the efforts to pass through the Violent Crime Control and Law Enforcement Act, and the Violence Against Women Act. He also chaired the Judiciary Committee through the contentious U.S. Supreme Court nominations of Robert Bork and Clarence Thomas. Biden unsuccessfully sought the Democratic presidential nomination in 1988 plus in 2008.

My genealogical chart shows the ancestor that Joseph Biden that connect us as family:

Joseph Robinett Biden Jr.
20th cousin 1x removed

Joseph Robinett Robinette Sr Biden Sr. (1915 – 2002)
Father of Joseph Robinett Biden Jr.

Mary Elizabeth Robbinette (1894 – 1943)
Mother of Joseph Robinett Robinette Sr Biden Sr.

George Tanner ROBINETTE (1756 – 1831)
Father of Mary Elizabeth Robbinette

Jesse ROBINETTE (1776 – 1832)
Father of George Tanner ROBINETTE

Moses J George Robinett (1819 – 1903)
Father of Jesse ROBINETTE

George H. Robinette (1844 – 1914)
Father of Moses J George Robinett

Nathan Robinette (1717 – 1803)
Father of George H. Robinette

Mary Taylor (1674 – 1747)
Mother of Nathan Robinette

William Taylor (1640 – 1683)
Father of Mary Taylor

William Taylor , Col. (1605 – 1687)
Father of William Taylor

Thomas Taylor , Cpt.
Father of William Taylor , Col.

Thomas Taylor (1548 – 1588)
Father of Thomas Taylor , Cpt.

Margaret Tyndal (1510 – )
Mother of Thomas Taylor

William Tyndal (1440 – 1488) Father of Margaret Tyndal

Thomas Tyndal (1411 – 1448)
Father of William Tyndal

Helena de Felbrigge (1390 – 1426)
Mother of Thomas Tyndal

Simon de Felbrigge (1367 – 1431)
Father of Helena de Felbrigge

Roger de Felbrigge (1342 – 1368)
Father of Simon de Felbrigge

Simon le Bigod (1281 – 1349)
Father of Roger de Felbrigge

Roger le Bigod (1242 – 1295)
Father of Simon le Bigod

Simon le Bigod (1218 – 1242)
Father of Roger le Bigod

Maud Marshall (1192 – 1248)
Mother of Simon le Bigod

Edward “Longshanks” King of England I, 17th great grandfather

King Edward I “Lingshanks” of England is my 17th great grandfather.

Edward I born on 17/18 June 1239 died on 7 July 1307. He was also called Edward Longshanks as well as the Hammer associated with the Scots, was King of England from 1272 to 1307. Before his accession into the throne, he was commonly described as The Lord Edward. The very first son of Henry III, Edward was involved from an early age in the political intrigues of his father’s reign, which included an outright rebellion because of the English barons. In 1259, he briefly sided with a baronial reform movement, supporting the Provisions of Oxford. After reconciliation together with father, however, he remained loyal through the subsequent armed conflict, known as the Second Barons’ War. After the Battle of Lewes, Edward was hostage towards the rebellious barons, but escaped after a few months and joined the fight against Simon de Montfort. Montfort was defeated at the Battle of Evesham in 1265, and within 2 yrs the rebellion was extinguished. With England pacified, Edward joined the Ninth Crusade towards the Holy Land. The crusade accomplished little, and Edward was on his way home in 1272 when he was informed that his father had died. Making a slow return, he reached England in 1274 and was crowned at Westminster Abbey on 19 August.

The is how King Edward I appears in my genealogical chart. I only went to my 5th great grandfather’s President Thomas Jefferson.

Edward “Longshanks” King of England I (1239 – 1307)
17th great-grandfather

Edward Plantagenet, King of England II (1284 – 1327)
Son of Edward “Longshanks” King of England I

Edward King of England (Plantagenet) III (1312 – 1377)
Son of Edward Plantagenet, King of England II

John Plantaganet Beauford Beaufort of Ghent Gent Gaunt, Duke of Aquitaine, “1st Duke of Lancaster” King of Castile PLANTAGENET (1340 – 1399)
Son of Edward King of England (Plantagenet) III

Joan Plantagenet Beaufort , Countess (1379 – 1440)
Daughter of John Plantaganet Beauford Beaufort of Ghent Gent Gaunt, Duke of Aquitaine, “1st Duke of Lancaster” King of Castile PLANTAGENET

Edward NEVILLE, Baron Bergavenny (1412 – 1476)
Son of Joan Plantagenet Beaufort , Countess

Catherine Neville (1442 – 1504)
Daughter of Edward NEVILLE, Baron Bergavenny

Anne Tanfield
Daughter of Catherine Neville

Elizabeth Vincent (1548 – 1589)
Daughter of Anne Tanfield

Dorothy Lane
Daughter of Elizabeth Vincent

Isham Randolph, Col. (1685 – 1742)
Son of Dorothy Lane

Jane Randolph (1720 – 1776)
Daughter of Isham Randolph, Col.

Thomas Jefferson President of the United States of America (1743 – 1826)
Son of Jane Randolph

William Shakespeare, 11th cousin 9x removed

William Shakespear is my 11th cousin 9x removed. The ancestor who connects us together is Maud Marshall (1192 – 1248), my 19th great grandmother.

William Shakespeare was baptize on 26 April 1564 and died on 23 April 1616. He had been an English poet, playwright and actor, widely seen as the best writer when looking at the English language and also the world’s greatest dramatist. He could be also known as England’s national poet and the “Bard of Avon”. His extant works, including collaborations, consist of approximately 39 plays, 154 sonnets, two long narrative poems, and a few other verses, some of uncertain authorship. His plays have been translated into every major living language and therefore are performed more frequently than those of any other playwright.

My genealogical chart showing the ancestor that William Shakespear and I share:

William Shakespeare (1564 – 1616)
11th cousin 9x removed

Mary Arden (1537 – 1608)
Mother of William Shakespeare

Thomas Arden
Father of Mary Arden

Thomas Arden
Father of Thomas Arden

Walter De Arden (1441 – 1502)
Father of Thomas Arden

Robert De Arden (1413 – 1452)
Father of Walter De Arden

Ralph De Arden (1373 – 1421)
Father of Robert De Arden

Henry De Arden
Father of Ralph De Arden

Ralph De Arden (1298 – )
Father of Henry De Arden

Alicia De Beauchamp (1270 – )
Mother of Ralph De Arden

Maud Fitz John De Shere (1237 – 1301)
Mother of Alicia De Beauchamp

Isabel Bigod
Mother of Maud Fitz John De Shere

Maud Marshall (1192 – 1248)
Mother of Isabel Bigod

Do you know your authentic-self?

Authentic people respond to their intrinsic motives. They exercise autonomy, dismiss introjected regulations, and choose one of the extrinsic motives accessible to them. Their thoughts, beliefs, words, and actions originate deep from within and therefore, are accurate and secure enough to resist negative external pressures. The result is an authentic, quiet, deep, vitalizing, serene, and lasting fulfillment and confidence without anxiety, self-doubt, or other types of stress.

Authentic people choose authentic alternatives. These generally include wisdom, true beliefs, valid conclusions, purposeful actions, candor, trust, placing needs in front of wants, knowing when they have enough, balancing gratification with hedonism, quick actions, treating others humanely, and establishing balanced relationships. We become authentic when the path we choose through life is congruent with who we are.

The alignment is essential to an authentic person. Actions aligned together with one’s authentic self are authentic behaviors. Actions misaligned with one’s authentic self are alien, false, fake, pretentious, aggravating, insincere, deceptive, tense, bogus, fake, and never authentic. This will be typical of an individual who is misaligned, off balance, exhausted, estranged, separated, and faking it. When everything one does is fully aligned with who one is, the person will be an authentic person. Authentic people “do who they are” and enjoy gratification, peacefulness, achievements, and worth. Authentic people act with an increase of interest, pleasure, and self-esteem and sometimes demonstrate better efficiency, perseverance, creativeness, vitality, self-esteem, and general well-being. Authenticity decreases worry, stress, shame, and embarrassment.

The power of positive thinking

Positive thinking does not suggest that one simply keep their head in the sand and disregard life’s less pleasing circumstances. Positive thinking just indicates that you address pain in a more positive and effective way. One believes the best will no doubt take place, not the most harmful.

Positive thinking often begins with self-talk. Self-talk is the countless stream of unexpressed ideas that run through ones brain. These automated ideas might be positive or unfavorable. Many of one’s self-talk proceeds from reasoning and justification. Other self-talk may possibly occur from misunderstandings that you generate mainly because of shortage of important information.

If the ideas that run through ones brain are commonly unfavorable, ones attitude on life is more likely cynical. If ones ideas are mainly positive, you are likely an optimist — a person who practices positive thoughts.

Researchers continue to discover the results of positive thinking and a positive outlook on wellness. Health advantages that positive thinking may render consist of:

  • Improved life span
  • Reduce rates of depression
  • Reduce levels of distress
  • Greater immunity to the common cold
  • Better psychological and bodily well-being
  • Better heart health and reduced risk of death from cardiovascular disease
  • Better problem management skills during hardships and times of stress

It’s ambiguous the reason why men and women who participate in positive thinking experience these health advantages. One principle is that having a positive frame of mind makes it possible for one to manage better with difficult circumstances, which decrease the damaging health consequence of strain on ones human body.

Hindu meditation is good for the body

In Hinduism (initially Sanatana Dharma), meditation has a place of significance. The fundamental objective of meditation is always to attain oneness associated with the practitioner’s spirit (atman with) omnipresent and non-dual almighty (Paramatma or Brahman). This state of one’s self is named Moksha in Hinduism and Nirvana in Buddhism. But as well Hindu monks and soon after Buddhist monks also are said to have achieved miraculous power by practicing meditation. The Hindu scriptures prescribe certain postures to achieve the state where the thoughts are in meditation. These positions are known as yoga. Clear references of yoga and meditation are located in ancient Indian scriptures like Vedas, Upanishads, and Mahabharata that features Gita. The Brihadaranyaka Upanishad defines meditation as having become calm and concentrated, one recognizes the self (atman) within oneself. Within the Hindu method of meditation you can find a set of rules to be followed in the process of yoga to successfully practice meditation. They are ethical discipline (Yamas), rules (niyamas), physical postures (asanas), breath control (pranayam), one-pointed concentration of mind (dharana), meditation (dhyana), and lastly salvation (samadhi). Hardly any can reach the stage of dhyana without the right knowledge and training from Guru, and fewer are thought to have reached the final stage. Gautama Buddha (originally Hindu prince), and Sri Ramakrishna, are thought to have been successful in achieving the final stage of salvation (samadhi)

Read more: Difference Between Hindu And Buddhist meditation | distinction between http://www.differencebetween.net/science/health/difference-between-hindu-and-buddhist-meditation/#ixzz5oDhEV4BF

Hinduism a beautiful religious tradition

Kenneth Dantzler-Corbin's avatarPhilosophy and Religious Insight

Hinduism may be the world’s oldest religion, relating to many scholars, with roots and customs dating back significantly more than 4,000 years. Today, with about 900 million followers, Hinduism could be the third-largest religion behind Christianity and Islam. Roughly 95 percent for the world’s Hindus live in India. Since the religion does not have any specific founder, it is difficult to trace its origins and history. Hinduism is unique in that it’s not a single religion but a compilation of numerous traditions and philosophies.

Some basic Hindu concepts include:

  • Hinduism embraces many religious ideas. This is exactly why, it’s sometimes described as a “way of life” or a “family of religions,” as opposed to an individual, organized religion.
  • Most forms of Hinduism are henotheistic, which means they worship an individual deity, referred to as “Brahman,” but still recognize other gods and goddesses. Followers believe you can find multiple paths to…

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