Category Archives: disease

Diet, disease, Fitness, Health, Healthy eating

Is calories, carbs, fat, fiber the unraveling problem linked between breast cancer and diet?

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A Low-Fat diet assists in easing the possibility of death from breast cancer. Though, dozens of news organizations, such as NPR, reported on innovative new research that discovered that a low-fat diet helped women minimize their danger of dying from breast cancer. However, the results stem through the federally funded Women’s Health Initiative; a significant, long-term, nationwide health study introduced back in 1993. At the time the analysis began, women who signed up were inside their 50s, 60s, and 70s.

The effectiveness of this research is twofold: its size, nearly 50,000 women in all, and its long-term follow-up, nearly 20 years. During the research, some ladies in both groups were identified as having breast cancer, but those that had altered their diets had a 21 percent lower danger of dying through the disease.

As soon as the females had been counseled to produce a lower-fat diet by eating more fresh fruits, veggies, and whole grain products, these people were doing significantly more than lowering fat; these were improving dietary fiber, nutrients, and vitamins.

The women into the study who modified their diets did lose weight, an average of about 3 percent of the total body weight. It is possible that this explains the decreased risk of death from breast cancer documented when you look at the study. It is evident that obesity is a risk factor for cancer of the breast, so shedding weight may be an approach to reduce risk.

Behavioral Science, disease, Health

Childhood stress affects the brain when one becomes an adult

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The human brain is a phenomenal body organ. It is responsible for ideas and emotions. It tells one’s muscles to move. It even can increase or decrease depending on what is occurring in ones setting. Now a brand new study discovers that going through severe instances as a kid also could have an influence. That stress can change the shape and shape of the human brain.

The adult brains of men and women who survived through lots of stress before the age of six — and then became despondent or anxious as young adults — were different than about older people who had a more carefree childhood. It seems that teens changed the shape of their brains by internalizing the pressures experienced years earlier — replaying those events in the head and keeping inside the emotions they induced.

Scientists already knew that the form and size of a child’s human brain could alter in responses to lots of stress. They also realized that adults were more likely to be depressed if, as children, they had been mistreated, was living in impoverishment, or faced other difficult times. Some scientific studies showed that these types of despondent adults had uncommon modifications in their brain contour. However, no one had tested whether the very early stress and later brain changes had been connected.

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Improved vaccinations against sexually transmitted infections

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In a research study published today when looking at the Nature Communications, researchers from King’s College London have shown how skin vaccination can generate protective CD8 T-cells which can be recruited into the genital tissues and might be used as a vaccination technique for sexually transmitted infections (STIs).

One of the challenges in developing vaccines for STIs, such for instance HIV or herpes simplex virus, is understanding how to attract specialized immune cells, called CD8 T-cells, to take up residence within the main body where in actuality the virus first enters. These cells have to be in position, armed and ready to provide an immediate protective immune defense, instead of waiting for immune cells when you look at the blood to enter the tissues which take some time.

Before this study, it was thought that vaccines ideally must be delivered straight to your body surface (e.g., female genital tissue) where the infection might start, so that the immune system can generate these CD8 T-cells, travel back to the vaccination site and eliminate any future virus this is undoubtedly encountered. However, delivering vaccines right to the sensitive genital tissue is neither patient-friendly nor efficient.

Now the team from King’s have discovered that their vaccination strategy marshals a platoon of immune cells, called innate lymphoid cells (ILC1) and monocytes, when you look at the genital tissues to your workplace together and release chemicals (chemokines) to send out a call to the CD8 T-cells generated by the vaccine to troop to the genital tissue.

This research builds in the team’s earlier work to develop skin vaccination techniques using a dis-solvable micro-needle vaccine patch that when placed from the skin dissolves and releases the vaccine without requiring a hypodermic needle injection and generates immune responses.

disease, Healthy eating

Did you know that genetically engineered immune cells fight off deadly virus in mice?

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Researchers may have demonstrated a novel way to safeguard us from some of the world’s deadliest viruses. By genetically engineering immune cells, which will make more effective antibodies, they usually have defended mice from a potentially lethal lung virus. Precisely the same strategy can work in humans against diseases, which are why there are not any vaccines. Though, vaccines typically contain a disabled microbial invader or shards of their molecules. They stimulate immune cells known as B cells to crank out antibodies that target the pathogen. Not every person who receives a vaccine gains protection, however. Some patients’ antibodies are not up to snuff, for example. Moreover, researchers have not been able to develop vaccines against some microbes, such for example HIV additionally the respiratory syncytial virus (RSV), that causes lung infections mainly in children and folks with impaired immune systems.

To find out whether transplanting the modified cells could prevent infections, the scientists injected the genetically engineered B cells or control cells into mice and then exposed the animals to RSV. Five days later, the lungs of this control mice teemed utilizing the virus. However, the lungs of mice that had received the engineered cells contained almost no RSV, the researchers report today in Science Immunology. As soon as the researchers injected the modified B cells into mice with defective immune systems—a common problem in bone marrow recipients, who will be prone to RSV—the rodents could fight off the virus 82 days later.

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Did you know that dangerous pathogens use sophisticated machinery to infect hosts?

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Gastric cancer, Q fever, Legionnaires’ disease, whooping cough—through the infectious bacteria that can cause these dangerous diseases are each different, each of them utilize the same molecular machinery to infect human cells. Bacteria make use of this machinery, called a Type IV secretion system (T4SS), to inject toxic molecules into cells and also to spread genes for antibiotic resistance to fellow bacteria. Now, researchers at Caltech have revealed the 3-D molecular architecture for the T4SS from the human pathogen Legionella pneumophila with unprecedented details. This might, in the foreseeable future, enable the growth of precisely targeted antibiotics for the diseases above.

There are nine different types of bacterial secretion systems, Type IV being the absolute most elaborate and versatile. A T4SS can ferry a multitude of toxic molecules—up to 300 at once—from a bacterium into its cellular victim, hijacking cellular functionality and overpowering the cell’s defenses.

Current antibiotics act broadly and wipe out bacteria through the body, including the beneficial microorganisms that are now living in our gut. As time goes by, antibiotics might be designed to block just the toxin delivery systems (including the T4SS) of harmful pathogens, rendering the bacteria inert and benign with no perturbing the body’s so-called “good bacteria.”

disease, Health

Watch for Tick, they spread disease

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Sometimes, particularly harsh winter will put a dent in Minnesota’s deer tick population. Think about it as nature’s way of rewarding humanity after a long, cold winter. Only deer ticks transmit Lyme disease.

Cold weather only kills ticks if they are confronted with the frigid air.

Ticks were insulated under a thick blanket of snow this winter, and so the bitter cold did not reach them.

The Health Department urges individuals who spend some time in brushy or wooded areas to safeguard themselves from ticks through the use of repellents which contain DEET, the same ingredient that wards off mosquitoes.

Much more useful are products that contain permethrin. However, Regular tick checks will also be recommended. One tip for locating the tiny deer ticks is always to step into the sunlight and look for reflections away from their backs.

Read more at: https://www.mprnews.org/story/2019/05/17/did-the-frigid-winter-take-a-toll-on-ticks

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Psoriatic Arthritis can be painful

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For those of you struggling with psoriasis, a severe condition of your skin there exists the potential to develop psoriatic arthritis. While no cure exists with this condition, it is imperative that the main focus stick to signs and symptoms and exactly how to avoid problems for the joints. With no treatment and a consignment to frequent exercise, psoriatic arthritis could be debilitating.

Although people with psoriasis and/or psoriatic arthritis may recognize periods of remission or instances when their symptoms seem to improve, both diseases are chronic and tend to worsen over time. Frequently, both the skin and also the joint issues can appear and disappear simultaneously.

Among the list of main outward indications of psoriatic arthritis are joint pain, stiffness, and swelling. These problems can affect any area of the body, even the fingertips, and the spine. They can range in degree from mild to severe. If you are experiencing psoriatic arthritis, you might notice pain when you look at the affected joints or swollen, warm-to-the-touch joints.

Read more at: https://www.medicalnewstoday.com/articles/322632.php

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What do you know about Hepatitis C?

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When you have hep C, you are not alone—about 3.4 million people are living with hep C in the United States. Hep C is a disease caused by a virus that infects the liver. A hep C infection can result in inflammation of this liver and result in the disease fighting capability to attack healthy liver cells. It could be spread through blood-to-blood contact or when the blood from a person with hep C comes into connection with another person’s blood.

Hepatitis C may be a silent disease, and therefore, people can have it although not have noticeable symptoms—approximately 70%–80% of people with acute hepatitis C do not have any symptoms. Many people, however, might have mild to severe symptoms soon after being infected.

As many individuals do not have any symptoms, they could not understand that they have hepatitis C, and therefore, do not seek treatment. Signs and symptoms of chronic hep C might take years to develop. During this time, the infected person can spread the virus to others.

Read more at: https://www.mavyret.com/about-hep-c?cid=ppc_ppd_msft_HCV_BV_2019_hepatitis_c_Exact_USVHCV190058&msclkid=99b5050589cf1a34303159db60324ba8

disease, Health

Chickens most likely caused the outbreak of Salmonella

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The Centers for Disease Control and Prevention says backyard chickens likely are behind the Salmonella outbreaks in 21 states.

The Tennessean reports the Thursday announcement says five men and women hospitalized and about 25 % for the total 52 infected individuals are underneath the chronological age of 5. Four associated with infected people reside in Tennessee.

A CDC news release says all of the ill individuals revealed having experience of chicks or ducklings, which it says were obtained through sources adding hatcheries and farming stores. The CDC says people could get sick from coming in contact with backyard poultry or their surroundings.

It says sick birds can take place clean without any signs and symptoms of illness. It says people ought to wash their hands after handling the birds and prevent touching their faces after snuggling all of them.

Read more at:https://nypost.com/2019/05/17/backyard-chickens-likely-cause-of-salmonella-outbreaks-cdc/

Behavioral Science, Culture, Diet, disease, Health, Healthy eating

Could a healthy diet cuts risk of dying from breast cancer in older women?

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A well-balanced, low-fat diet significantly lowers the risk of dying from breast cancer in postmenopausal women, based on new long-term data from the Women’s Health Initiative (WHI) Dietary Modification trial.

The balanced diet designed is one of moderation, and after nearly 20 years of follow-up, the health benefits are still accruing.

The findings revealed during a press briefing May 15 ahead of a presentation Jun 2 during the American Society of Clinical Oncology (ASCO) annual meeting.

This research makes clear there are not any down-sides, only up-sides to a more healthy diet, plus it adds to a growing level of studies showing similar positive effects across cancer types.

The trial enrolled 48,835 postmenopausal women without any previous breast cancer and with dietary fat accounting for at the very least 32 per cent of total daily calories. From 1993 to 1998, the women were randomly allocated to a usual-diet comparison group or a dietary intervention group that aimed to cut back fat intake to 20 per cent of daily calories and increase consumption of vegetables, fruit and grains.

Women into the balanced, low-fat diet group stuck with the diet for roughly 8.5 years. Many of them increased their intake of fruits, vegetables and grains and cut their daily fat intake to 25 per cent or less, although most did not reach the 20 per cent goal.

An overall total of 3,374 women developed breast cancer between 1993 and 2013. The low-fat diet failed to significantly reduce women’s risk of developing cancer of the breast – still, women within the dietary intervention group experienced a range of short- and long-term health advantages in comparison with women within the normal diet group. Specifically, that they had a 21 per cent lower danger of death from breast cancer and a 15 per cent lower chance of death from any cause through the follow through period.

Postmenopausal women with metabolic syndrome (increased blood pressure, high blood glucose, excess excessive fat around the waist and abnormal cholesterol or triglyceride levels) were particularly prone to benefit from the dietary intervention.

Find out more at https://www.channelnewsasia.com/news/world/healthy-diet-cuts-risk-of-dying-from-breast-cancer-in-older-women-11540664
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