Tag Archives: coronary heart disease

How reliable are the findings that suggest emulsifiers in processed foods may increase cardiovascular risk, and what further research is needed to confirm or refute this association?

A ground-breaking study by The BMJ sheds harsh light on the potential dangers lurking within our favorite processed foods in a shocking revelation that could shock the food industry. Brace yourself for this unsettling truth: those seemingly harmless emulsifiers, the very substances that make our indulgent treats extra mouthwatering, might actually be silently plotting against our cardiovascular health. Yes, you read that right. The very same additives found in pastries, ice cream, and ready meals could be putting our hearts at risk. It’s time to take a closer look at what we’re really consuming.

Food additives, including emulsifiers, undergo regular safety assessments based on the scientific evidence available. However, recent studies indicate these emulsifiers may disrupt gut bacteria and heighten inflammation levels, potentially increasing susceptibility to cardiovascular problems.

To investigate the potential health risks further, researchers in France undertook a study to establish possible links between exposure to emulsifiers and the risk of cardiovascular disease, including coronary heart disease and cerebrovascular disease. These diseases affect blood flow and blood vessels in the heart and brain. The study involved 95,442 French adults with no history of heart disease and averaged follow-up records for seven years. Participants provided detailed dietary records and any major CVD events they experienced.

The study revealed that higher intake of specific types of emulsifiers—total celluloses (E460–E468), cellulose (E460), and carboxymethylcellulose (E466)—was positively correlated with higher risks of CVD and, specifically, coronary heart disease. In addition, higher intakes of monoglycerides and diglycerides of fatty acids (E471 and E472) were related to higher risks across all studied outcomes. Among these emulsifiers, specific types were associated with higher risks of CVD and cerebrovascular diseases.

It is essential to note that this is an observational study and cannot definitively establish causality. The researchers acknowledged limitations such as the high proportion of women and the generally higher educational background of the participants, which may affect the generalizability of the findings. Despite these limitations, the study could prompt a reevaluation of regulations concerning the use of food additives in the food industry to protect consumers.

Given these findings, several public health authorities recommend reducing the consumption of ultra-processed foods to limit exposure to these potentially harmful additives. This study serves as a cautionary note, urging both the public and regulatory bodies to scrutinize the long-term effects of substances that are so widely incorporated into modern diets.

According to the text, the specific types of emulsifiers that are positively correlated with higher risks of CVD and, specifically, coronary heart disease are total celluloses (E460–E468), cellulose (E460), and carboxymethylcellulose (E466). The text also mentions that recent studies indicate these emulsifiers may disrupt gut bacteria and heighten inflammation levels, potentially increasing susceptibility to cardiovascular problems. To limit exposure to these potentially harmful additives, several public health authorities recommend reducing the consumption of ultra-processed foods.

Cited Works:
News-Medical.net. “High Intake of Emulsifiers May Increase Risk of Cardiovascular Disease,” September 7, 2023 https://www.news-medical.net/news/20230907/High-intake-of-emulsifiers-may-increase-risk-of-cardiovascular-disease.aspx.

Komulainen, Pirjo. “The Association of Vascular and Neuroprotective Status Indicators with Cognitive Functioning: Population-Based Studies (Verisuonisairauksien RiskitekijöIden Ja AivoperäIsen HermokasvutekijäN Yhteys Kognitiiviseen Toimintakykyyn – VäEstöTutkimus)” https://core.ac.uk/download/pdf/15167220.pdf.

Interleukin-1 has been involved as a mediator of chronic pericarditis

Interleukin-1 has been involved as a mediator of chronic pericarditis. A phase 3 trial of rilonacept was performed in patients with acute symptoms and systemic inflammation. During the run-in period, the median time for pain resolution or near-resolution was 5 days, and the median time for normalization of CRP was 7 days. Injection site reactions and upper respiratory tract infections were the most common adverse events. Among patients with chronic periecarditis, treatment resulted in rapid resolution and a slightly lower risk of recurrence than placebo. The most common side effects were injection site reactions and upper respiratory tract infections.

Reference

Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis. https://www.nejm.org/doi/full/10.1056/NEJMoa2027892

Guidelines prescribe that one or more antiarrhythmic medications

Guidelines prescribe that one or more antiarrhythmic medications be tested before catheter ablation is considered in patients with atrial fibrillation. First-line ablation could be more effective in preserving sinus rhythm, we’ve discovered. Severe adverse effects resulted in 5 patients who underwent ablation and 6 patients who prescribed antiarrhythmic drug treatment. Patients undergoing initial care for symptomatic, paroxysmal atrial fibrillation had a slightly lower risk of recurrence with catheter cryoballoon ablation than with antiarrHythmicDrug, as measured by continuous heart rhythm testing. The median ratio of time of atrial fibrillation was 0 per cent (interquartile scale, 0 to 0.08) with ablation and 0.13 per cent with drug treatment compared to 0.60 per cent with ablated therapy.

Reference

Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation. https://www.nejm.org/doi/full/10.1056/NEJMoa2029980