Tag Archives: Men

disease, Health

It is amazing how drugs make headway against lung, breast, and prostate cancers

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Newer drugs are substantially improving and enhancing the chances of survival for some individuals with hard-to-treat forms of lung, breast, and prostate cancer, doctors, reported at the world’s largest cancer conference.

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Immunotherapy drugs such as Keytruda have transformed the various treating types of cancerous tumors, but they’re still relatively new and don’t help most patients. The most extensive study yet of Keytruda in patients with advanced lung cancer discovered that 23 percent of those who got the drug as an element of their initial therapy survived at least five years, whereas 16 percent of those who tried other treatments first did. The risk of this rises with age, but about 48,000 cases each in the U.S. are in women under age 50 years. About 70 percent are “hormone-positive, HER2-negative” — that is, cancer’s growth is fueled by estrogen or progesterone and not by the gene that the drug Herceptin targets.

In research of 672 women with such cancers that had spread or been very advanced, adding the Novartis drug Kisqali to the usual hormone blockers as initial therapy helped more than hormone treatment alone.

After 3½ years, 70 percent of females on Kisqali were alive, compared to 46 percent for the remainder. Side effects were more typical with Kisqali.

This is the very first time any treatment has boosted survival beyond what hormone blockers do for such patients.

The choices keep expanding for men with prostate cancer that has spread beyond the gland. Standard therapy is drugs that block the male hormone testosterone, which helps these cancers grow, plus chemotherapy or even a newer drug called Zytiga.

Now, two other drugs have proved to extend survival whenever used like chemo or Zytiga in guys who were getting natural hormone therapy and still being helped by it.

One study tested Xtandi, sold by Pfizer and Astellas Pharma Inc., in 1,125 guys, half of whom also were chemo that is getting. After three years, 80 % of those offered Xtandi plus standard treatments were alive, contrasted to 72 percent of men given the other treatments alone. The other research involved 1,052 guys who got hormone treatment with or minus the Janssen drug Erleada. After two years, success was 82 percent among those on Erleada and 74 percent those types of who wasn’t.

Men now have a range of four drugs that provide comparable benefits, with no studies yet have compared them against one another, said Dr. Ethan Basch, a prostate specialist at the University of North Carolina’s Lineberger Comprehensive Cancer Center who may have no financial ties to any drugmakers.

However, chemo can cause numbness and tingling in the tactile arms and feet and may even maybe not be suitable for men with diabetes who already are at higher risk because of this problem. Zytiga must be studied having a steroid; Xtandi and Erleada can cause fainting and falling.

Chemo has more side effects, but it costs much less and requires only four to six intravenous treatments. One other three medications are pills that cost more than $10,000 a month and tend to be taken indefinitely.

Reference
Drugs make headway against lung, breast, prostate cancers …. https://www.everyday-scoop.com/drugs-make-headway-against-lung-breast-prostate-cancers-the-associated-press/

Culture, Health

Did you know that men have a biological clock?

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For females, it is well-known that postponing having children right up until middle age can be dangerous, for both their health and the health of their baby. However, males have not been an integral part of that image. So far. A new study indicates males ought to be conscious of their particular biological clocks, also.

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Males, who may have young children at the age of 45+ place their particular companions at an increased risk regarding pregnant problems and the children, possess increased dangers associated with birth abnormalities, childhood cancers, along with other health problems, as outlined by a research released in Maturitas. Experts examined four decades worth of scientific studies on how parental age impacts male fertility, being pregnant, and a child’s health and wellness as time passes.

The results come at any given time where many people are stalling having children. Fathers who have children at the age of 45 has risen by 10percent in American over the last 40 years. To track the trends, the main risks mentioned in the study are pregnancy, fertility, and children’s health and wellbeing. Scientist found that only men who were 45 and older experience a decrease in fertility, or whether they wanted children, their companions may encounter high risk associated with being pregnant with complications, for example, gestational diabetes and early labor and birth. The statistical data furthermore revealed that their children had a higher risk of difficulties such as low scores on the Apgar test, a fundamental evaluation utilized to evaluate a baby’s heart rate, inhaling and exhaling, and general health, low birth bodyweight, congenital cardiovascular disease, and cleft palate.

The possible problems continued as the children got older. Children born to older father have a high risk of mental and physical health issues, which includes childhood cancer, mental or cognitive disorder, and possible autism.

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Bachmann takes into account the organic aging process as the real cause of the majority of such problems, even though she cautions that more research is needed to explain how they are all connected genuinely. As males grow older, their testosterone amounts decrease, and the quality of the semen and sperm begins to weaken at the same time, which helps make clear the male fertility problems in older men often cope. Additionally, getting older may cause genetic changes in men sperm, and these variations may clarify the relationship involving high paternal age group and increased probability of medical issues in their children.

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The research study illustrates the crucial understanding of how fertility change with age, regardless of one’s gender.

The study does not suggest that one should have children when they are young. Sperm banks give couples options. However, some researchers suggest that men who may want children could consider banking their sperm for they reach the age of 35.