Obesity has almost tripled globally since 1975. Total dietary replacement techniques have become widely shared in the fight against obesity. High-protein diets have been found to support weight loss and maintenance. Studies showed that high-protein total dietary replacement contributed to higher energy consumption, accelerated fat oxidation, and negative fat balance” The findings provide more proof that calories are not just calories, says Dr. Peter Wexler, author of a recent study on high-protein total dietary replacements. The research has been published in the American Journal of Clinical Nutrition. It was tested on stable, normal-weight adults aged 18 to 35 years.
A higher protein diet may contribute to an increase in energy expenditure and fat oxidation. High-protein complete dietary substitutes could be a potential food approach to tackle increasing obesity rates. Future experiments are expected in order better to understand the long-term implications of this dietary experiment.

Reference
Are high-protein total diet replacements the key to maintaining healthy weight?. https://www.eurekalert.org/pub_releases/2020-11/asfn-aht111220.php