During the trial period, individuals who had moderate quantities of coffee, even with a little sugar, were 30 percent less likely to die than those who did not consume coffee.

Researchers analyzed coffee consumption data obtained from the U.K. Biobank, a vast medical database including health information on the whole nation’s population. Three to five cups of unsweetened coffee per day was associated with the lowest mortality risk. Inconclusive were the data for persons who consumed coffee with artificial sweeteners. Other lifestyle factors, such as a healthy diet and frequent exercise, may also contribute to a reduced risk of death.

Coffee users may pick cold brew or drip coffee over less healthy caffeine sources, such as energy drinks or soda. Coffee beans have high quantities of antioxidants, which may help neutralize cell-damaging free radicals. Over time, an accumulation of free radicals may induce inflammation in the body, which can contribute to the formation of plaque associated with heart disease. Those who drank more than 4.5 cups of coffee each day had diminishing benefits.